Various theories attribute this clinical variability to different sources: microbial variability in the microbiological theory, environmental variability (not including that of the pathogen considered but potentially including that of other microbes) in the ecological theory, somatic immunity variability (adaptive and acquired) in the immunological (or somatic) theory, and germline immunity variability ( intrinsic, innate, and adaptive immunity) in the genetic theory. The fundamental enigma in the field of infectious disease is the tremendous clinical variability between individuals in the course of infection ( Figure 1). INTRODUCTION: THREE COMPLEMENTARY THEORIES Finally, we consider the far-reaching biological and clinical implications of the ongoing human genetic dissection of severe infectious diseases. We also illustrate its recent achievements by highlighting inborn errors of immunity underlying eight life-threatening infectious diseases of children and young adults. We present here the genetic theory of infectious diseases and briefly discuss its history and the challenges encountered during its emergence in the context of the apparently competing but actually complementary microbiological and immunological theories. Over the past century, this idea has gained some support, particularly among clinicians and geneticists, but has also encountered resistance, particularly among microbiologists and immunologists. Population and clinical geneticists soon proposed a complementary hypothesis, a germline genetic theory of infectious diseases. This powerful explanation is, however, best applicable to reactivation and secondary infections, particularly in adults it can less easily account for interindividual variability in the course of primary infection during childhood. Moreover, interindividual variability in the course of infection was typically explained by the emerging immunological (or somatic) theory of infectious diseases, best illustrated by the impact of vaccination. Paradoxically, this observation barely challenged the newly developed notion that infectious diseases were fundamentally extrinsic. However, around the turn of the twentieth century, asymptomatic infection was discovered to be much more common than clinical disease. The germ theory of diseases then gradually overcame the belief that diseases were intrinsic.
#System shock 2 french epstein code#
You'll get the code in ops.Until the mid-nineteenth century, life expectancy at birth averaged 20 years worldwide, owing mostly to childhood fevers. Use the assault rifle and EMP rifle from the closet on medical that Bronson locks (over by the first OS upgrade). The assault rifle is good in general based on the ammo type you have equipped, whereas the EMP rifle does similar damage with a lesser cost to mechanical enemies. With your high tech and weapon skills you should be able to keep a fully modified assault rifle and EMP rifle (my favorite weapons). After that you'll probably want to focus on getting STR to 3 and maintenance to 3-4 to start wearing some good armor and keeping your weapon acquisitions in order. You should focus on getting hack up to 2 or 3, standard to 6, and research to 1 as early as possible in the game. If you're going for a purist build like melee, psi is helpful in boosting stats and damage and dealing out additional AoE damage, if you're playing coop and want to do an energy build you can get the power that recharges your electrical stuff, etc.
Psi is mostly a means to specialize since it takes a lot of investment for the skills that aren't banal. If you set endurance to 4 and hack to 5, for example, you can up heavy to 6 and then be able to use pretty much all the useful weapons in the game besides the crystal shard (a great melee weapon, though pretty much the only useful exotic weapon, and from what I remember it does no damage to the final boss).Īs for O/S upgrades, the most universal ones will probably be cybernetically enhanced (could probably use an agility boost and endurance boost implant on this build), sharpshooter, speedy, and IMO lethal weapon if you run out of ammo or don't feel like using any.
#System shock 2 french epstein plus#
You can fiddle with it I'd probably recommend taking out discretionary points from endurance if you're playing at medium difficulty, plus max hacking isn't truly necessary, although convenient. This assumes you pick up all or most of the modules in the game though, so go scrounging for them: Here's an all-rounder build I put together a while back.
0 kommentar(er)
